There is proof with the induction of CYP2A6 in vivo by phenobarbital as well as other anticonvulsant medications. Two-working day treatment method with phenobarbital (one hundred mg daily p.o.) just before a liver biopsy resulted in induction of metabolism of nicotine to cotinine in hepatocytes (Kyerematen et al. Potentials issues https://maindistro.com/