For many of the nineteenth century, drugs weren't really productive, main Oliver Wendell Holmes Sr. to famously remark in 1842 that "if all medicines on the earth were being thrown into the sea, it would be all the higher for mankind and many of the worse for the fishes".[27]: 21 https://arzneimittel21975.rimmablog.com/29471172/arzneimittel-an-overview