For example, the diversion of methadone and buprenorphine from opioid agonist cure is documented for being a big problem in certain nations around the world (see Section Artificial opioid trafficking). Potent artificial opioids, such as the fentanyl by-product carfentanil and benzimidazole (nitazene) opioids, eaten in the context of polydrug use, https://dutchcartel.eu/product-tag/order-heroin-online/